11 factors that negatively affect IVF success

If there are recurrent implantation failures and miscarriages in your IVF journey, what would you say to gain knowledge by learning the factors that negatively affect this process?

If you have applied for IVF treatment to become a mother or father, you should know that this process is not easy at all. Although many drugs and many unfamiliar terms may overwhelm you at times, remember that you are using this method for a good cause.

Recurrent implantation failure is relevant only to patients undergoing assisted reproductive technology treatment. Three or more IVFs; defined as embryo transfer failure. Recurrent pregnancy loss is defined as three or more pregnancy losses. There are several factors as to why IVF may not work for you;


Maternal age is an important factor responsible for the quality of embryos. In addition, the risk of aneuploidy (abnormal number of chromosomes) increases with advancing age, which is not a preferred condition in IVF treatments.


A maximum body mass index (BMI) of 25 is one of the factors affecting fertility. IVF patients require higher doses of gonadotropins, but usually fewer eggs are retrieved compared to a normal BMI patient. It also affects the quality of the eggs and ultimately the quality of the embryo.

3. DNA fragmentation

High DNA fragmentation of sperm is associated with poor quality embryos that cannot be implanted or aborted in early pregnancy.


Smoking increases the risk of miscarriage. It has also been found in several studies that smoking reduces the level of estrogen in the body and can also affect the corpus luteum, which secretes progesterone, leading to IVF failure.


Endometriosis is a condition in which the endometrium grows outside of the uterine cavity and secretes certain immunological factors that inhibit implantation and cause repeated implantation failure.

6. Myomas

Fibroids can cause both recurrent implantation failure and recurrent pregnancy loss. Fibroids are non-cancerous growths from the muscle of the uterus. They can be found in the cavity (submucosal), in the muscle (intramural), or on the outside of the uterus (subserosal). Submucosal fibroids need to be removed regardless of their size, as they can hinder the implantation and growth of the baby.

Depending on size, number, and other factors, intramural fibroids may or may not require removal. Subserosal fibroids did not have any effect on implantation or pregnancy.


Polyps are also non-cancerous growths that arise from the lining of the uterus and can interfere with implantation, such as a submucosal fibroid. It must be removed before conception, before repeated cycles of implantation failure in recurrent miscarriages.


It is a condition in which menstrual bleeding occurs within the uterine muscle. Adenomyosis is strongly associated with both recurrent implantation failure and recurrent pregnancy loss. It is associated with changing the uterine environment to make it hostile to the embryo. Also, there is increased uterine contractions in adenomyosis, which increases the risk of miscarriage. It is even associated with adverse pregnancy outcomes in the 2nd and 3rd trimesters.


There are unicornuate, bicornuate, septate uterus, etc. associated with both recurrent implantation failure and recurrent pregnancy loss. There are various uterine abnormalities such as These abnormalities must be treated before pregnancy.


Hypothyroidism is associated with infertility and recurrent pregnancy loss. Even a small correction in thyroid levels is associated with better pregnancy outcomes.

Low thyroid hormone levels can prevent the release of an egg from your ovary (ovulation), which impairs fertility.


APS is a condition in which small thrombi form inside the veins and capillaries. This leads to recurrent miscarriages and may be associated with recurrent implantation failure. Blood tests may be done to see if a patient has APS. Precautions can be taken to prevent these complications.

Apart from these factors, infection, thin endometrium, chronic diseases, immunological factors, molecular factors etc. There are other factors that may be responsible for these situations.


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