PGD to increase the success rate in IVF
Choosing the right embryo in the IVF treatment process is important for a healthy treatment process. Therefore, choosing the embryo with the best health status and the highest chance of attachment is determined by Preimplantation genetic testing.
Emphasizing that PGD should be applied to couples who are at risk of a single gene disease, namely hemophilia, cystic fibrosis, and common cell anemia, Prof. Dr. Yücel Karaman, “PGD (Preimplantation Genetic Diagnosis) allows the genetic structures of embryos formed in in vitro fertilization treatment to be examined before they are transferred to the uterus. In this way, the chance of IVF success increases and the risk of pregnancy resulting in miscarriage decreases. It also reduces the need for medical termination of pregnancy and prevents unhealthy pregnancy. provides,” he says.
What is preimplantation genetic diagnosis (PGD)?
- Preimplantation Genetic Diagnosis (PGD) is applied to diagnose whether the embryo is normal in terms of the chromosomes examined and genetic diseases.
- In this method, genetic testing is performed on quality embryos that have reached the 3rd or 5th day after the eggs are fertilized in the laboratory in IVF treatment.
- With the test, information can be obtained about whether the embryo carries any genetic disease or whether it is chromosomally normal.
How is preimplantation genetic diagnosis (PGD) done?
- Before pregnancy occurs, a cell sample is taken from the embryo on the 3rd and 5th days obtained by in vitro fertilization.
- One or two cell biopsies are taken from the embryos and chromosomal tests are performed.
- Biopsy embryos are followed.
- The process is completed by transferring healthy embryos without any problems to the mother’s womb.
In which situations is preimplantation genetic diagnostic testing recommended?
- In recurrent pregnancy loss
- If the fetus has a chromosomal abnormality in the history of miscarriage
- If you are a carrier of translocation in the mother or father or both
- If the mother or father has a sex-related single gene disease
- If the mother or father has a single gene disease or carrier
- If HLA compatible-tissue compatible embryos will be obtained for the treatment of the diseased child (conditions requiring marrow transplantation)
- In couples with single gene diseases with preimplantation genetic diagnosis
