Polycystic ovary syndrome in IVF treatment

The number of eggs in women with polycystic ovary syndrome is much higher than normal. While we evaluate 8-12 eggs in a woman as normal, this number is based on serious numbers in women with this syndrome.

How do people with polycystic ovaries get pregnant? Is it good or bad to have many eggs in women with polycystic ovaries, is the number or quality of eggs important? The most confusing questions… PCOS (polycystic ovary syndrome) is the group that our expectant mothers do not like at all, but our favorite group in our IVF treatments. First of all, it is seen in one out of 10 women in the world. First of all, PCOS is a chronic condition. In other words, a woman is born with this syndrome already in her mother’s womb. Women of reproductive age often come to us with complaints such as menstrual irregularity, hair growth and rapid weight gain. This syndrome is noticed when the appearance of polycystic ovaries in the ultrasound we do in women who apply, or when the hormones, especially amh, that is, the ovarian reserve is higher than four. In addition, additional diseases such as goiter or high milk hormone should be excluded, as these diseases can be confused with PCOS. In a woman, ovulation does not occur in the 14 days before menstruation. Therefore, the period of conception can be calculated by subtracting 14 days from the total cycle and not including the menstrual period. A woman who menstruates every 28 days ovulates in the first 14 days, while a woman who menstruates once in 35 days ovulates in the first 21 days. Since ovulation will not occur during menstruation, a relationship is recommended between the end of menstruation and 14 days before the next menstruation. Pregnancy often comes spontaneously when the sperm fertilizes this cracked egg.


In women with polycystic ovary appearance, the number of eggs once is much higher than the normal number. Under normal conditions, we consider 8-12 eggs in a woman as a normal number, but with our women with pcos, this number is based on serious numbers. So much so that I know that I collected 117 eggs. Despite having so many eggs, this is the situation where the eggs cannot be cracked, and unfortunately, we may not be able to see the pregnancy situation in these couples because the eggs cannot fertilize the sperm. In polycystic ovary syndrome, this number of eggs is accompanied by menstrual irregularity. We recommend our women and girls who come to us with PCOS to lose 10 percent of their weight first. Because as I mentioned, rapid weight gain is one of its most visible features. We often observe that with weight loss, egg quality increases five times. We especially recommend the Mediterranean diet. Then we recommend folic acid and vitamin D supplements. These supplements are important because we see vitamin D deficiency in most of our women with PCOS. Again, we see sugar resistance in many of our PCOS group women. In our women in this group, we start sugar resistance regulating medication. This is our indispensable pre-treatment model for our couples who come for a child request and all women with pcos syndrome. Of course, 80 percent of our couples who come for a child request, whose diagnosis of pcos we have revealed through examinations and tests, and for which we plan our pre-treatment, respond positively to this treatment, and our natural pregnancy occurs spontaneously. However, there is also 20 percent of this group, which unfortunately cannot respond positively to our treatment. After this process, we go to the egg follow-up, which is our second stage, we grow the eggs with drugs and crack them, if the sperm values ​​are good and the tubes are open, we recommend a relationship with the spouse. We can often get pregnant again within six months. In this way, we start in vitro fertilization treatment for our group, for whom we could not get a response and could not get pregnant. Well, you will now ask, why are people with pcos syndrome the favorite group of me and many of my IVF doctors in my opinion? For one thing, there is no such thing as a shortage of reserves, which really requires a very tiring and grueling treatment. In other words, we have plenty of eggs from which to obtain embryos. All we have to do is apply our treatment that will make these eggs even better. Then, when we combine the eggs we collect with our sperm, which we have made better with our treatment, under the best laboratory conditions, we transfer our best quality embryo on the fifth day. And of course we catch the pregnancy.

by Prof. Dr. Gökalp Öner


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