IUI (Vaccination) is the process of introducing the sperm cell taken from the male into the woman’s uterus during the ovulation period. This treatment can be recommended to couples who have problems with the sperm cells passing through the uterus to the tubes and fertilizing the egg cell.
Who Is Vaccination Applied?
Patients with insufficient sperm count and mobility
Erection (hardening of the penis) disorders
Retrogad ejaculation (ejaculation is into the bladder in the opposite direction instead of the mouth of the penis)
Female patients having antibodies that damage sperm cells
Patients with moderate endometriosis
Patients with unexplained infertility
In order for vaccination to be applied, at least one of the patient’s tubes must be open, and the number, movement and morphology of the sperm cells (percentage of normal-looking sperm) must be within the limits that can be vaccinated.
Preparation Period for Vaccination
During the vaccination period, drugs are given externally to stimulate the ovaries. The aim of these drugs is to provide a healthy follicle (the structure containing egg cells) in the ovaries.
Egg Development Tracking
Egg development is followed by ultrasonography and hormone analysis. Ultrasonography, also called USG, helps to track the size of the egg cell. This size tracking is very important for treatment, because when the follicle size reaches around 17-18 mm, it means it is ready to crack. In hormone analysis, estrogen and LH hormones are measured. The increase in estrogen hormone indicates a healthy follicle development. The LH hormone, on the other hand, shows a sudden increase during the ovulation period, causing the follicle to crack and the egg cell to be released. After the released egg cell passes into the tubes, it is fertilized by the sperm cell. These measurements are of great importance in follow-up, as an unexpected rise in the LH hormone may cause premature cracking of the egg and inability to vaccinate.
Frequency of Follow-up
The sick menstruation is 3-5. starts to use medicines in days. 8-9. On days, USG and hormone tests are started and the dose is adjusted and after that, the follow-up is continued every other day.
How to Determine the Time of Ovulation?
When the follicle size reaches 18-20 mm in USG, it is cracked by administering HCG hormone from the outside with the help of a needle. This hormone causes the follicle to crack and the egg cell to be released.
Pain relievers should not be used unless absolutely necessary, close to the ovulation period. Many pain relievers negatively affect ovulation.
During the treatment process, sexual life can be continued.
If you have a medication that you regularly use, please inform your doctor at the beginning of your treatment.
Do not use medication without the knowledge of your doctor.
Avoid radiation (x-ray film, etc.).
The sperm sample taken from the male on the day of vaccination is passed through a series of processes, the sperm cells that are most likely to fertilize the egg cell are separated and injected into the uterus with the help of a plastic cannula called a catheter.
Vaccination is a painless procedure that does not require anesthesia.
It takes between 10 and 15 minutes on average.
After the vaccination process is completed, you can leave the clinic.
You do not need to make any restrictions in your sexual life after the procedure.
If you have any unexpected vaginal bleeding, please consult your doctor.
Risks of Treatment
Multiple pregnancy: Since the drugs used for vaccination may cause more than one follicle development in the ovaries, there is an increase in the rate of multiple pregnancy.
Hyperstimulation syndrome: Ovaries can sometimes over-respond to drugs used, which may cause enlargement of the ovaries and, in severe cases, rarely, accumulation of water in the abdomen.
The ovaries do not respond to the drugs used: Rarely, the ovaries may respond insufficiently to the drugs used, which causes the vaccination not to be performed that month.
Premature cracking of the follicle: Follicle cracking may be earlier than expected due to the unexpected rise of the LH hormone, which causes the vaccination not to be performed that month.
Chance of Success
The success rate of vaccination treatment is around 15-20% per treatment. If the male partner’s sperm count is within normal limits and the woman’s tubes are healthy, this chance can reach up to 50% after a few attempts within a year. If successful, after 3-4 vaccination cycles on average, IVF is recommended.